Review Finds Radiotherapy May Convert Breast Cancer Into In Situ Vaccine.

Wednesday, December 6, 2017

Cancer Therapy Advisor (12/6, Furlow) reports on a “review of preclinical and early human trial data” presented at the San Antonio Breast Cancer Symposium finding that “radiotherapy’s pro-immunogenic effects might improve the antitumor efficacy of immune checkpoint inhibition.” Silvia Formenti, MD, of Weill Cornell Medicine, in New York, New York, said, “Most breast cancers may require multiple immunotherapeutic interventions to become an in situ vaccine.” Dr. Formenti said that the review supports using “3 to 5 doses of 8 Gy each when radiotherapy is combined with immunotherapy.